Some time after the Mousekewitz's have settled in America, they find that they are still having problems with the threat of cats. That makes them eager to try another home out in the west, where they are promised that mice and cats live in peace. Unfortunately, the one making this claim is an oily con artist named Cat R. Waul who is intent on his own sinister plan. Unaware of this, the Mousekewitz's begin their journey west, while their true cat friend, Tiger, follows intent on following his girlfriend gone in the same direction.

美國鼠譚2：西部歷險記是由Phillip,Glasser,James,Stewart,Erica,Yohn,Cathy,Cavadini,Nehemiah,Persoff,Dom,DeLuise主演的動漫全集,在1991年拍攝美國上映播出,好劇屋提供了美國鼠譚2：西部歷險記,美國鼠譚2：西部歷險記高清版,美國鼠譚2：西部歷險記免費在線觀看,并且還可以支持手機看,不需要下載播放器,方便廣大影迷。